Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane
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منابع مشابه
Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane.
The dopaminergic system is essential for cognitive processes, including reward, attention and motor control. In addition to DA release and availability of synaptic DA receptors, timing and magnitude of DA neurotransmission depend on extracellular DA-level regulation by the dopamine transporter (DAT), the membrane expression and trafficking of which are highly dynamic. Data presented here from r...
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Several previous human postmortem experiments have detected an increase in striatal [(3)H]WIN 35428 binding to the dopamine transporter (DAT) in chronic cocaine users. However, animal experiments have found considerable variability in DAT radioligand binding levels in brain after cocaine administration, perhaps caused by length and dose of treatment and type of radioligand used. The present exp...
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The trafficking of synaptic proteins is unquestionably a major determinant of the properties of synaptic transmission. Here, we present a detailed analysis of the downregulation and intracellular trafficking of the cocaine- and amphetamine-sensitive dopamine transporter (DAT), a presynaptic plasma membrane protein responsible for the regulation of extracellular DA concentrations. Using PC12 cel...
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Dopaminergic signaling and plasticity are essential to numerous CNS functions and pathologies, including movement, cognition, and addiction. The amphetamine- and cocaine-sensitive dopamine (DA) transporter (DAT) tightly controls extracellular DA concentrations and half-life. DAT function and surface expression are not static but are dynamically modulated by membrane trafficking. We recently dem...
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THE APICAL NA -K -2CL COTRANSPORTER of the thick ascending limb (TAL; NKCC2) plays a critical role in the countercurrent multiplication mechanism that drives urinary concentration in response to vasopressin (16). The paper by Ortiz (20) in this issue of AJP-Renal Physiology nicely complements prior work on the regulation of NKCC2 by vasopressin and cAMP, highlighting the role of transporter tra...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms10423